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Fig. S1 shows that PDE-5 inhibitors reduce tumor growth but that persistent tumors show evidence of immune editing. In Fig. S2, the antitumor effect of sildenafil is maintained even with delayed treatment. Fig. S3 shows that sildenafil increases CD8+ TILs. Fig. S4 depicts sildenafil as it fails to induce an antitumor effect in 4T1-HA–bearing Rag-2–/– mice. In Fig. S5, sildenafil fails to augment proliferation of purified T cells. Fig. S6 shows that sildenafil does not alter IL-13 or IFN- production from CD11b+ cells. Online supplemental material is available at http://www.jem.org/cgi/content/full/jem.20061104/DC1.
Mission & History
Action for a Better Community is a Community Action Agency that promotes and provides opportunities for low-income individuals and families to become self-sufficient.
The Promise of Community Action
Community Action changes people's lives, embodies the spirit of hope, improves communities, and makes America a better place to live. We care about the entire community, and we are dedicated to helping people help themselves and each other.
Action for a Better Community, Inc. is one of nearly 1,000 nationally recognized Community Action Agencies (CAAs), established under the Economic Opportunity Act of 1964 to fight America's War on Poverty. CAAs serve 98% of our nations cities and counties and are a primary source of support for the more than 38 million Americans living in poverty in both rural and urban areas. ABC continuously emphasizes Community Action's identity in our area as a viable, working solution to moving people out of poverty.
©2000-2012 Action for a Better Community, Inc.
550 E. Main Street | Rochester, NY 14604
(585) 325-5116 | (585) 325-9108 - fax